                         SEQUENCE LISTING

<110>  XBiotech USA, Inc.
       Simard, John
 
<120>  Interleukin-1alpha Antibodies and Methods of Use

<130>  5407-0024

<150>  US 61/057,586
<151>  2008-05-30

<150>  US 61/121,391
<151>  2008-12-10

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  471
<212>  PRT
<213>  homo sapiens

<400>  1

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Met Phe Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ala Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Ile Leu Phe Leu Gln Met Asp Ser Leu Arg Leu Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Arg Pro Lys Val Val Ile Pro Ala Pro Leu 
        115                 120                 125             


Ala His Trp Gly Gln Gly Thr Leu Val Thr Phe Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Gln Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Leu Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  2
<211>  1416
<212>  DNA
<213>  Homo sapiens

<400>  2
atggagttcg ggctgagttg ggtgttcctg gtggctctgc tgcggggcgt gcagtgccag       60

gtgcagctgg tggagagtgg gggtggcgtg gtgcagcctg gccggtctct gcgcctgtct      120

tgcactgcct ccggttttac cttttctatg tttggtgtgc actgggtgcg ccaggctccc      180

ggcaagggac tggaatgggt ggccgccgtg agttacgacg ggtccaacaa atattacgct      240

gagagcgtga aaggcagatt caccatcagc agagataatt ccaagaatat tctgttcctg      300

cagatggaca gtctgagact ggaggacact gctgtgtact actgcgctcg tggacgccct      360

aaggtggtca tccccgcccc cctggcacat tggggccagg gaactctggt gaccttttct      420

agcgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtccacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtagtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gcccagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccctgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctcctt aagtccggga aaataa                               1416


<210>  3
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu Glu Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Thr Ser Ser Phe Leu Leu Ser Phe Gly Gly Gly Thr Lys Val Glu His 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  4
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  4
atggacatgc gcgtgcccgc ccagctgctg gggctgctgc tgctgtggtt ccctggatct       60

aggtgcgaca ttcagatgac ccagtccccc agctcagtgt cagcctccgt gggcgacaga      120

gtgacaatca cctgccgcgc ctctcaggga atctctagtt ggctggcctg gtaccagcag      180

aagcctggaa aggcccccaa gctgctgatc tatgaagcct ccaacctgga gaccggcgtg      240

ccctctcgct tcagcggctc aggctcaggc agtgatttta ctctgaccat cagctccctg      300

cagccagagg atttcgctac ttactactgc cagcagacct cttccttcct gctgtccttc      360

gggggaggca caaaggtgga gcaccgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagtt caccggtgac aaagagcttc aacaggggag agtgttag                   708


<210>  5
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Met Phe Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ala Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Ile Leu Phe Leu Gln Met Asp Ser Leu Arg Leu Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Arg Pro Lys Val Val Ile Pro Ala Pro Leu 
        115                 120                 125             


Ala His Trp Gly Gln Gly Thr Leu Val Thr Phe Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  6
<211>  1422
<212>  DNA
<213>  Homo sapiens

<400>  6
gccaccatgg agtttggtct gtcctgggtg ttcttggtgg ctctgctgag gggggtgcag       60

tgccaggtcc agctggtgga gtctggtggg ggagtggtgc agcctgggag atctctgcgg      120

ctgtcttgca ctgcctctgg tttcactttc tctatgtttg gtgtgcattg ggtcaggcaa      180

gcaccaggca aaggactcga gtgggtcgca gctgtgagct atgacgggtc taacaaatat      240

tacgctgagt ctgtcaaggg taggtttacc atcagccggg ataattccaa aaatatcctg      300

ttcctgcaaa tggactctct gaggctggaa gatactgcag tctactattg tgcaaggggg      360

aggccaaagg tggtgatccc cgctcccctc gctcactggg gacagggaac cctggtgact      420

ttcagctctg ctagcaccaa gggccctagc gtgttcccat tggctccttc ctccaaatct      480

acttctggag gcaccgccgc cctgggatgt ctcgtgaaag attattttcc tgagcccgtc      540

accgtgagct ggaacagcgg cgccctgact agcggcgtgc acacctttcc cgcagtgctg      600

caatctagcg ggctgtactc cctgagctct gtcgtgaccg tgccctccag cagcctcgga      660

actcagacct acatctgcaa tgtcaatcat aaaccctcta ataccaaagt cgataagaag      720

gtcgaaccta aatcttgcga taaaacccat acctgccccc cttgcccagc acccgaactg      780

ctgggcggtc cctctgtgtt tctgttcccc cccaaaccca aagataccct gatgatctct      840

aggacccccg aggtcacttg tgtcgtggtg gatgtgtccc acgaagatcc agaagtcaaa      900

ttcaactggt atgtggacgg ggtcgaagtg cacaacgcaa agaccaagcc tagggaggaa      960

cagtataata gcacatatag ggtggtcagc gtcctgaccg tcctgcatca ggactggctg     1020

aatggcaaag aatataagtg taaagtgtcc aacaaggccc tgccagcccc aatcgaaaag     1080

acaatctcta aagccaaggg gcaaccccgg gaacctcagg tctatacact gccaccctct     1140

cgggatgaac tgaccaagaa tcaggtgagc ctgacatgtc ttgtgaaggg tttttatccc     1200

tccgacattg ccgtggagtg ggagagcaat ggacaaccag aaaataacta caaaaccaca     1260

ccccctgtgc tggactccga tggttccttc ttcctctact ctaagctgac agtggataag     1320

tctaggtggc agcaggggaa tgtgttctcc tgctctgtga tgcacgaggc actgcacaat     1380

cattatacac aaaagtctct gtctctgtct ccaggaaagt aa                        1422


<210>  7
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu Glu Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Thr Ser Ser Phe Leu Leu Ser Phe Gly Gly Gly Thr Lys Val Glu His 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  8
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  8
gccaccatgg acatgcgcgt tcctgcccag ctcctcggac tgctgctgct ttggttccca       60

ggctcccggt gtgatattca gatgacacag tctccctcct ccgtatctgc atccgtgggc      120

gacagggtca caatcacttg tagggccagc caggggatct ctagttggct cgcatggtac      180

caacaaaagc caggtaaggc tccgaaactg ctcatttacg aagctagtaa cctcgaaaca      240

ggcgtgccaa gccggtttag cggctccggt tccggttctg acttcaccct cactatttcc      300

tccctgcaac ctgaggattt tgccacatat tactgtcagc aaacttcttc ttttctgctc      360

tcctttggtg ggggaactaa ggtggagcac acagtggccg cccccagcgt ctttatcttc      420

cccccaagcg atgaacagct gaagtcaggg accgccagcg tggtctgcct gctcaataat      480

ttttaccctc gcgaggctaa ggtccaatgg aaagtggata acgccctcca gagcggtaac      540

tctcaggagt ctgtcacaga gcaagacagc aaggatagca cctattccct ctccagcacc      600

ctgacactgt ctaaggccga ctacgagaaa cacaaagtgt acgcttgtga ggtgactcac      660

cagggactga gtagccctgt gacaaaatct ttcaataggg gagaatgctg a               711


<210>  9
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Met Phe Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ala Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Ile Leu Phe Leu Gln Met Asp Ser Leu Arg Leu Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Arg Pro Lys Val Val Ile Pro Ala Pro Leu 
        115                 120                 125             


Ala His Trp Gly Gln Gly Thr Leu Val Thr Phe Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  10
<211>  1422
<212>  DNA
<213>  Homo sapiens

<400>  10
gccaccatgg agtttggtct gtcctgggtg ttcttggtgg ctctgctgag gggggtgcag       60

tgccaggtcc agctggtgga gtctggtggg ggagtggtgc agcctgggag atctctgcgg      120

ctgtcttgca ctgcctctgg tttcactttc tctatgtttg gtgtgcattg ggtcaggcaa      180

gcaccaggca aaggactcga gtgggtcgca gctgtgagct atgacgggtc taacaaatat      240

tacgctgagt ctgtcaaggg taggtttacc atcagccggg ataattccaa aaatatcctg      300

ttcctgcaaa tggactctct gaggctggaa gatactgcag tctactattg tgcaaggggg      360

aggccaaagg tggtgatccc cgctcccctc gctcactggg gacagggaac cctggtgact      420

ttcagctctg ctagcaccaa gggccctagc gtgttcccat tggctccttc ctccaaatct      480

acttctggag gcaccgccgc cctgggatgt ctcgtgaaag attattttcc tgagcccgtc      540

accgtgagct ggaacagcgg cgccctgact agcggcgtgc acacctttcc cgcagtgctg      600

caatctagcg ggctgtactc cctgagctct gtcgtgaccg tgccctccag cagcctcgga      660

actcagacct acatctgcaa tgtcaatcat aaaccctcta ataccaaagt cgataagagg      720

gtcgaaccta aatcttgcga taaaacccat acctgccccc cttgcccagc acccgaactg      780

ctgggcggtc cctctgtgtt tctgttcccc cccaaaccca aagataccct gatgatctct      840

aggacccccg aggtcacttg tgtcgtggtg gatgtgtccc acgaagatcc agaagtcaaa      900

ttcaactggt atgtggacgg ggtcgaagtg cacaacgcaa agaccaagcc tagggaggaa      960

cagtataata gcacatatag ggtggtcagc gtcctgaccg tcctgcatca ggactggctg     1020

aatggcaaag aatataagtg taaagtgtcc aacaaggccc tgccagcccc aatcgaaaag     1080

acaatctcta aagccaaggg gcaaccccgg gaacctcagg tctatacact gccaccctct     1140

cgggaggaaa tgaccaagaa tcaggtgagc ctgacatgtc ttgtgaaggg tttttatccc     1200

tccgacattg ccgtggagtg ggagagcaat ggacaaccag aaaataacta caaaaccaca     1260

ccccctgtgc tggactccga tggttccttc ttcctctact ctaagctgac agtggataag     1320

tctaggtggc agcaggggaa tgtgttctcc tgctctgtga tgcacgaggc actgcacaat     1380

cattatacac aaaagtctct gtctctgtct ccaggaaagt aa                        1422


<210>  11
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu Glu Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Thr Ser Ser Phe Leu Leu Ser Phe Gly Gly Gly Thr Lys Val Glu His 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  12
<211>  717
<212>  DNA
<213>  Homo sapiens

<400>  12
gccaccatgg acatgcgcgt tcctgcccag ctcctcggac tgctgctgct ttggttccca       60

ggctcccggt gtgatattca gatgacacag tctccctcct ccgtatctgc atccgtgggc      120

gacagggtca caatcacttg tagggccagc caggggatct ctagttggct cgcatggtac      180

caacaaaagc caggtaaggc tccgaaactg ctcatttacg aagctagtaa cctcgaaaca      240

ggcgtgccaa gccggtttag cggctccggt tccggttctg acttcaccct cactatttcc      300

tccctgcaac ctgaggattt tgccacatat tactgtcagc aaacttcttc ttttctgctc      360

tcctttggtg gaggaactaa ggtggagcac aagcggacag ttgctgctcc tagcgtcttt      420

atcttccctc caagcgatga acagctgaag tcagggaccg ccagcgtggt ctgcctgctc      480

aataattttt accctcgcga ggctaaggtc caatggaaag tggataacgc cctccagagc      540

ggtaactctc aggagtctgt cacagagcaa gacagcaagg atagcaccta ttccctctcc      600

agcaccctga cactgtctaa ggccgactac gagaaacaca aagtgtacgc ttgtgaggtg      660

actcaccagg gactgagtag ccctgtgaca aaatctttca ataggggaga atgctga         717


